The technologies used in the creation of VDO.Ninja are application agnostic. It doesn’t know how the output URL is being used.
To that end, any software that can use a browser-based source or has window-capture capabilities should be compatible with VDO.Ninja. This includes VMix, ManyCam, custom Electron.js-based applications, and more.
Please note, VDO.Ninja is tested to be compatible with OBS (obsproject.com), and there are some added OBS-specific optimizations included with VDO.Ninja. Tally lights may not work for example with other software.