While Safari may work with VDO.Ninja, it is generally advised to not use Safari with macOS. The microphone may become muted if the tab is minimized, echo-cancellation doesn't quite work as well as with Chromium-based browsers, video/audio issues are more common, and many of the advanced features offered by VDO.Ninja are not supported on non-Chromium-based Browsers. Consider using the Electron Capture app if adverse to installing or using Chrome, as it is based no Chromium but community created specifically for VDO.Ninja.